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Superconducting computing circuits were briefly heralded as the future of computing in the 1980s. Columnist Karmela Padavic-Callaghan visits a quantum chip foundry where one company is betting this technology’s second act will revolutionise quantum computers

Although he took softball questions from MAHA sycophant Bari Weiss, Dr. Vinay Prasad, a public servant, refuses to leave his safe space to answer tough, but fair questions from credible reporters like Lizzy Lawrence.

The post Why Does Dr. Vinay Prasad Refuse to Answer Questions About His Job Performance at the FDA? first appeared on Science-Based Medicine.

Green hydrogen could be a game-changer for the clean energy transition—but right now, it’s too expensive and still relies on harmful “forever chemicals.” A new EU-backed project called SUPREME aims to fix that by reinventing how hydrogen is made. Led by the University of Southern Denmark with partners across Europe, researchers are developing a PFAS-free electrolysis system that slashes the use of rare metals like iridium and dramatically cuts costs.

NASA’s Carbothermal Reduction Demonstration (CaRD) project completed an important step toward using local resources to support human exploration on the Moon.

The congenital condition spina bifida is often treated surgically in the womb, but many children still go on to have mobility issues. The addition of a patch made up of stem cells from donated placentas could improve their long-term outcomes

In the span of just weeks, two major U.S. releases captured the nation’s attention: Bugonia, Yorgos Lanthimos’s darkly playful alien tale, and The Age of Disclosure, a documentary staged like science fiction, where whistleblowers insist that nonhuman craft exist and the government is concealing the truth about alien contact. Their timing is not accidental. Both arrived on the heels of the first public congressional UFO hearings in over fifty years, in the middle of a nationwide spike in reported sightings. The All-domain Anomaly Resolution Office (AARO) documented 757 new UAP (Unidentified Anomalous Phenomena) incidents between May 2023 and June 2024—more than in many previous years combined—and some analysts now describe 2025 as the most active reporting year in history. We are not just witnessing reports of the unexplained; we are witnessing the psychic temperature of a country—its anxieties, conspiratorial hunger, and collective imagination—made visible.

At the end of Bugonia, when the alien empress finally speaks—exactly as the conspiracy theorist had foretold—she delivers her verdict to her crew, all of them dressed in strange, animal-like furred spacesuits: “We believe it is over. They have had their time. And in their time they have imperiled the life they share, and so we have decided their time will end.” The aliens then waddle away in eerie unison, and the empress punctures the protective Earth bubble. What follows is an instant apocalypse: humanity wiped out in a scene that resembles the visual language of the Rapture—a sudden and absolute religious experience. 

Poster for Bugonia (2025), directed by Yorgos Lanthimos. Image courtesy of Focus Features/CJ ENM

But The Age of Disclosure, Dan Farah’s latest sci-fi-styled documentary production, framed as a serious exposé of government UFO secrecy, ultimately reveals nothing new. It offers no evidence, only a procession of interchangeable older men linked to government or aerospace who repeat secondhand stories about witnesses who said they back-engineered crashed spaceships, recovered “biologics” (the new fancy term for aliens), and looming threats. At the watch party I attended, a few of us sat nonplussed at the end because, although the film insists danger is near, we wondered: danger from what, exactly? 

Why are aliens capturing our cultural imagination now? 

Most alien or UFO reports1 involve sightings of lights, orbs, or spheres that move oddly or swiftly and vanish silently—a pattern that has remained consistent over time. Some observers also report cigar-shaped objects or triangular craft. Many of these phenomena are reported worldwide. In 2025, the National UFO Reporting Center had already logged 2,174 UFO/UAP reports by midyear, a sharp increase from 1,492 reports during the same period in 2024. This rise may reflect the establishment of the AARO and renewed government attention, which have made reporting easier and less stigmatized, not to mention nudging people to look up more and notice what was previously missed (Starlink satellites are often reported as UAPs). Increased public awareness through media coverage, documentaries, and congressional hearings also encourages people to report sightings they might previously have ignored. This explanation, of course, presumes the alien sightings are real. Are they? 

An alternative interpretation—commonly referred to as the Psychosocial UFO Hypothesis—traces back to Swiss psychologist Carl Jung, whose 1958 work Flying Saucers: A Modern Myth of Things Seen in the Sky, proposed that UFOs reflect psychic and cultural realities, not extraterrestrial ones.2 Jung suggested that flying saucers emerge in the collective imagination during eras of social disorientation, technological upheaval, or existential threat, functioning as modern myths that carry the weight of collective anxiety and longing. Rather than evidence of literal beings from another world, UFOs become symbols of fear, hope, salvation, or invasion—a projection of what the psyche cannot resolve. From this view, alien encounters are psychologically real even if not physically tangible: They reveal something true about the human mind and the cultural moment, not necessarily the cosmos. 

It is unsurprising that UFO sightings are on the rise today. Scholars have observed that UFO reports tend to increase during periods of societal crisis—such as existential uncertainty, geopolitical tension, or rapid technological change—reflecting collective anxieties rather than objective phenomena.3 In times of social distress and distrust, people are more likely to assign meaning or threat to ordinary or ambiguous events. Some psychological-cognitive theories suggest that ambiguous stimuli—lights in the sky, radar blips, or unexplained objects or events—are interpreted through cultural narratives and heightened pattern seeking.4 This is sometimes called the “low information zone,” in which blurry photographs and grainy videos stimulate the mind to fill in the missing spaces or connect the dots into meaningful patterns of an extraterrestrial nature. 

We live in a time of deep distrust in politics, corporations, and the media, which makes people question what they are told. Heightened fears from draconian COVID policies (“they closed the schools, restaurants, and parks so the pandemic must be really bad!”), hypermediated climate collapse (“if we don’t do something in twelve years all is lost”), threats of rising fascism (“Trump, MAGA!”), threats of an AI takeover (“the singularity is near!”), and rising nihilistic political violence (“burn it all down and start over!”) have created a pervasive state of anxiety. This fear, combined with distrust of formerly trusted institutions, fuels conspiracy thinking, including beliefs about aliens. With few reliable frameworks to navigate uncertainty, many turn outward for explanations or as distractions from personal responsibility. 

In Bugonia, Lanthimos suggests that conspiracy beliefs often emerge as a response to real pain and injustice. The film’s central conspiracist grew up with an addicted, neglectful mother and later lost her to a medical experiment. His belief in aliens and corporate malevolence is not baseless; it is rooted in trauma, exploitation such as pharmaceutical misconduct and corporate neglect, and social alienation. In this way, the film does not simply mock conspiracists as “crazy,” but explores the social and psychological conditions that give rise to such beliefs. 

To these we can add two more conditions contributing to Americans’ increasing belief in UFOs: the decline of religious faith and a reduced reliance on instinct and common sense. 

As traditional faith wanes, many turn to belief systems grounded not in evidence or instinct but in ideology and narrative—UFO conspiracies being a prime example. Belief is migrating from shared moral and religious frameworks to culturally mediated myths that promise meaning and belonging. In this sense, aliens function as a modern sacred avatar, a substitute for God, mystery, and existential structure. 

This mindset—that what you see may not be true, or what you don’t see is probably true—has fundamentally contributed to the widespread and enduring belief in a U.S. government cover-up of UFOs.

The complexity of contemporary society has been linked to a reduced dependence on intuitive judgment and common sense, making individuals more susceptible to being drawn into ideology and conspiracy theories.5 This effect has been amplified over the last two decades by our deep immersion in the online world, coupled with persistent global political instabilities. These factors have ushered in an era of “alternative facts” (on the right) and “postmodernism” (on the left) for many Americans, where the core assumption is that there is more than one truth or no truth at all. 

This mindset—that what you see may not be true, or what you don’t see is probably true—has fundamentally contributed to the widespread and enduring belief in a U.S. government cover-up of UFOs. Thus, even though most individuals have never personally seen or experienced a UFO firsthand, they are readily pulled into the conspiratorial narrative and accept it primarily because of the powerful surrounding cultural and ideological framework. It’s ideology over instinct. 

Common Sense and Instinct 

Evolutionarily, humans developed heuristics to make rapid decisions in uncertain environments—recognizing patterns, detecting threats, and navigating social hierarchies. These shared mental shortcuts form a basis of common knowledge, allowing groups to act cohesively, from identifying safe foods and interpreting emotional cues to cooperating in collective tasks. This intuitive knowledge also extends to social cognition: Humans can rapidly infer intentions, predict behavior, and synchronize actions with others, often without conscious reasoning. In this sense, common knowledge is not arbitrary but adaptive, providing a shared framework that increases survival, cooperation, and cultural stability. As Steven Pinker argues, common knowledge is foundational to human society because it enables social coordination and complementary decision making.6 Much of this understanding operates beneath awareness, signaled through involuntary behaviors like laughter, tears, blushing, eye contact, and blunt speech—embodied expressions of the intuitive knowledge that binds us. 

Paradoxically, people often engage in elaborate efforts to obscure, ignore, or deliberately avoid acknowledging common sense and, tragically, their own instincts. The tendency to avoid recognizing widely shared knowledge is well-documented in psychology and sociology. This behavior, known as information avoidance, allows individuals to shield their happiness, preserve existing beliefs, or maintain social standing. Research also shows that information avoidance can serve as a coping mechanism in situations of uncertainty or threat, helping people reduce cognitive dissonance and emotional discomfort.7

People sometimes engage in information avoidance not merely to protect their beliefs or personal happiness, but to align with a group ideology and secure a vital sense of belonging. According to Social Identity Theory,8 individuals derive meaning, status, and self-esteem from the groups they belong to; consequently, they may reject information that threatens the group’s worldview. Specifically, people may set aside their personal instincts or empirical skepticism to be part of a community—be it political, spiritual, ideological, or conspiratorial—that claims to possess special, hidden, or insider knowledge. Aligning with a group that asserts access to deeper truths, secret insights, or a more “awakened” understanding often feels more meaningful and elevating to one’s identity than simply accepting one’s ordinary, concrete life.9

In addition, people often bypass common sense by relying on cognitively unfalsifiable ideas—using claims for aliens such as “trans-dimensional,” “telepathic,” or “unperceivable by ordinary minds,” which place the phenomenon in a realm where no evidence could ever contradict it. This creates epistemic shielding, where the claim becomes immune to challenge: Any lack of proof is simply reframed as expected, since the phenomenon supposedly exists beyond ordinary perception or logic.10 This often involves setting aside common-sense reasoning—such as the implausibility of coordinated alien visits, the immense logistical challenges of secrecy, or the extreme hazards of space travel. By suspending these rational doubts, individuals can fully engage with the group, strengthening both cohesion and commitment to shared beliefs like UFOs. 

Believing the government hides alien knowledge signals social intelligence and alignment with the modern order of suspicion, whereas trusting official explanations can appear naïve or even irrational—suggesting that disbelief in conspiracy has become more deviant than belief itself.

System Justification offers another cogent explanation for why people override instinct, even without empathy-driven motives. This psychological process leads individuals to defend and reinforce the prevailing system or worldview, even when it may run counter to their own interests.11 In the context of UFO belief, the dominant “system” is no longer governmental authority but rather the conspiratorial worldview itself. Institutional distrust has become the cultural status quo, so accepting the narrative of a cover-up functions as a way of justifying and maintaining that system.12 Believing the government hides alien knowledge signals social intelligence and alignment with the modern order of suspicion, whereas trusting official explanations can appear naïve or even irrational—suggesting that disbelief in conspiracy has become more deviant than belief itself. 

A further reason that common sense is bypassed in UFO narratives stems from a psychological profile that makes the alien stories uniquely meaningful to the participants. The key players in The Age of Disclosure documentary, reflecting the wider UFO conspiracy community, are largely older White men, often from the Baby Boomer generation, including many former Cold War intelligence and military personnel. They were trained for decades to perceive patterns, secrets, and threats everywhere, interpreting anomalies like radar returns, classified flights, and black-project aircraft. This environment rewarded suspicion, dramatic interpretation, and assuming hidden motives—a mindset that doesn’t simply switch off upon retirement. Once retired, many lose their high status and sense of purpose; they miss being “in the know” and having a mission. UFOs restore all of that, allowing them to be relevant again by “exposing secrecy,” “protecting humanity,” and “warning people about what’s coming.” This powerful way of restoring identity and meaning creates a significant blind spot for rational facts or instinct, cementing a narrative where they matter again. 

A more common-sense approach—one uninfluenced by ideology—would align closely with how neuroscientists are beginning to frame the perception of unidentified objects. A trio of researchers, for example, recently posed this question: How can we “explain why healthy, intelligent, honest, and psychologically normal people might easily misperceive lights in the sky as threatening or extraordinary objects, especially in the context of WEIRD (western, educated, industrial, rich, and democratic) societies”?13 These researchers draw on predictive-coding theories of perception, which suggests that the brain constantly generates top-down predictions based on prior experience. When sensory input is ambiguous or weak, such as distant lights in the sky or other celestial stimuli, perception becomes highly subject to existing beliefs and expectations. Frohlich, Christov-Moore, and Reggente argue that in Western contexts, where skepticism and distrust of institutions are amplified, psychologically normal people are more likely to interpret ordinary phenomena as potentially extraordinary, thereby reinforcing their mistaken beliefs and fostering the acceptance of conspiratorial explanations.14

Illustration by Marco Lawrence for SKEPTICDecline of Traditional Faith 

Another factor reinforcing the heightened interest and belief in UFOs is the dramatic decline of traditional faith systems in the U.S. and globally, especially in Europe.15 We are living through a moment of profound spiritual and cultural upheaval, marked by widespread secularization. Data from the Pew Research Center’s Religious Landscape Studies (2007–2024) clearly illustrate this shift in the United States: The share of Americans identifying as Christian has dropped significantly from 78 percent in 2007 to 62 percent in 2023–2024. Much of this shift is driven by the growth of the religiously unaffiliated—those identifying as atheist, agnostic, or “nothing in particular”—the “nones.” Furthermore, a stark generational divide exists, as only approximately 46 percent of younger Americans (ages 18–24) identify as Christian, contrasted with about 80 percent of older generations. Related measures of religious practice have also declined, including the share of Americans who believe in God “with absolute certainty,” pray daily, or attend regular services. 

These trends are not isolated to the U.S., reflecting global secularization that affects major world religions, including Christianity, Islam, Judaism, Buddhism, and Hinduism. A 2023 analysis of the World Values Survey data found that age and income are among the strongest predictors for decreasing religiosity, confirming that modern economic and demographic shifts correlate strongly with this decline.16 The consequence of the decline in traditional religious structures (churches, organized faith, and institutional religion) is the creation of a spiritual and cultural void. This vacuum can then be filled by alternative spiritualities, existential searches, or other belief systems that offer meaning, structure, and a sense of the transcendent—including UFOs, alien-mythologies, “otherworldly” beliefs, and nature mysticism. 

As younger generations grow up without strong religious roots, their search for meaning and a comprehensive moral framework often shifts toward political, psychiatric, or identity-based frameworks rather than centuries-old orthodox religions. While these new frames of belief are influenced by contemporary cultural anxieties, they tend to be less stabilizing and reassuring than traditional faith and wisdom. Studies of the culture wars indicate that, instead of offering equanimous guidance, these ideologies frequently contribute to an “us versus them” positionality, demanding allegiance to a specific side rather than fostering broad acceptance or spiritual integration.17, 18, 19

A Desire for Faith 

When social anxieties intersect with waning religious practices, a spiritual void emerges, which faith, in its deepest sense, functions to fill. Paul Tillich described faith as the recognition of what is ultimately important in life, providing meaning and courage in the face of despair.20 Faith counters the secular demand to find fulfillment solely in the material present by offering a framework of ultimate value that extends beyond the empirical, fostering trust that reality holds order, purpose, and goodness beyond human comprehension. While it does not remove suffering, faith situates pain within a larger narrative of redemption or spiritual growth, offering hope, belonging, and the resources to endure the “unlivable self.” In this light, participation in alien beliefs can, in part, be interpreted as a search for a similarly powerful spiritual experience. 

For Carl Jung, the emergence and widespread cultural interest in alien experiences and UFOs were a form of spiritual projection. He posited that this phenomenon arose from a collective longing for something transpersonal—a desire for meaning and connection beyond the material world—driven largely by the decline of traditional spiritual practice and the sociopolitical existential crisis in the West. Jung argued that, regardless of their physical reality, what UFOs primarily represent to people is the archetype of salvation or integration, serving as a potent symbol of hope that something external might save humanity from its own crises. 

This powerful psychological need quickly spilled into the social sphere: By the early 1950s, the world saw the beginning of UFO religious communities, almost all of which were tied to the emerging New Age Movement.21 This established a distinct, if unconventional, religious community that has since expanded into a diverse landscape of cults, spiritual groups, and online movements. These modern mythologies offer their adherents not only an answer to the cosmic riddle but also a sense of belonging, a moral framework, and a promise of ultimate transformation—functions historically reserved for organized religion. 

We are not just witnessing reports of the unexplained; we are witnessing the psychic temperature of a country—its anxieties, conspiratorial hunger, and collective imagination—made visible.

The world of UFOs deeply echoes religious communities, particularly in how the phenomenon inherently divides people into believers and nonbelievers, subsequently demanding an alignment with a collective ideology or community for those who accept the narrative. In particular, abduction narratives strongly resemble spiritual transformation stories, carrying powerful mythic, symbolic, and spiritual overtones that speak to a profound human need. These experiences often involve narratives of a calling, being chosen, initiation, and transformation, placing the individual in touch with a greater, transcendent, and mysterious unknowable power.22 In this way, both alien abduction and traditional spiritual experiences—such as deep prayer, apparitions, mystical visions, or spiritual possession—can be viewed as powerful modern myths. They serve as psychic containers for deeper psychological realities, suggesting they both function as potent cultural frameworks for expressing profound feelings of internal conflict, such as disconnection, trauma, or identity crisis, and a fundamental longing for transcendence or an escape from the confines of a prescribed self. 

If participation in UFO belief systems satisfies a spiritual longing, what’s the harm? Perhaps none. However, when such belief requires individuals to suppress instinct, embodied perception, and common sense, the stakes shift. We risk creating tension with the fundamental architecture of evolutionary biology and psychology. To override these deeply ingrained perceptual systems in favor of a socially constructed narrative demands a significant cognitive sacrifice—one that erodes the innate trust in our instincts that has historically kept us alive. Over time, this override may dull the very intuition evolution shaped to help us discern reality from story. 

We cannot expect young Americans to find faith in religious institutions, as many are still working to repair the trust of congregants they have long disenchanted. Yet faith—faith in something, anything—is essential to begin filling the emptiness left by a lack of meaning. Without faith in a larger cosmic order—be it a sense of karma, a belief in something greater, or a feeling of being loved or held by a transcendent whole—our younger generations are far more likely to attach to an ideology introduced to them on social media, which often leaves them unattached to an embodied instinctual reality. 

Into this void step alien narratives.

Complex Organic Molecules (COMs) are important building blocks for life. They can form in space and be delivered to planets. But new research shows some of them can form in circumplanetary disks where moons form, boosting the prospects for life in Europa's ocean.

Genetic evidence hints that there was a strong bias for male Neanderthals and female humans to mate, rather than any other combination

Legislation working its way through the UK parliament would ban children from using social media and virtual private networks – but the proposals would endanger online privacy and may not make children safer, say legal experts

Researchers have discovered new ways to shape quantum light, creating high-dimensional states that can carry much more information per photon. Using advanced tools like on-chip photonics and ultrafast light structuring, they’re pushing quantum communication and imaging into exciting new territory. Although long-distance transmission remains tricky, innovative approaches—such as topological quantum states—could make these fragile signals far more resilient. The momentum suggests quantum optics is entering a bold new phase.

Researchers have discovered new ways to shape quantum light, creating high-dimensional states that can carry much more information per photon. Using advanced tools like on-chip photonics and ultrafast light structuring, they’re pushing quantum communication and imaging into exciting new territory. Although long-distance transmission remains tricky, innovative approaches—such as topological quantum states—could make these fragile signals far more resilient. The momentum suggests quantum optics is entering a bold new phase.

A dying star has ejected its outer layer and illuminated it with its powerful radiation. The resulting nebula looks every bit like a transparent human skull. Astronomers are calling the unusual structure the Exposed Cranium Nebula.

If skies are clear, don’t miss one of the top astronomical events of the year this coming Tuesday, March 3rd, as the Moon passes through the Earth’s shadow in a total lunar eclipse. This will be a fine leisurely affair centered around the Pacific Ocean region, with totality lasting almost an hour in duration. For many observers worldwide, this is the last total lunar eclipse until late 2028 and mid-2029.

Scientists at the University of Oxford have finally settled a decades-long mystery about the Moon’s magnetic field — and it turns out both sides were right. By reanalyzing Apollo mission rocks, they discovered that the Moon did occasionally generate an incredibly powerful magnetic field, even stronger than Earth’s — but only for fleeting bursts lasting thousands of years or less. Most of the time, the Moon’s magnetic field was weak.

The news is abuzz with talk of a potential universal respiratory vaccine. It’s definitely interesting research, but may not be what you think. In this case, the reporting has been quite good on the whole, but the headlines can be misleading if you are not deeply steeped in the complexities of mammalian immunity. Let me start with the biggest caveat – this is a mouse study. This is therefore encouraging pre-clinical research, but we are still years away from translating this into an actual vaccine. Also, most interventions that are encouraging at the animal stage don’t make it through human testing. So don’t expect any revolution based on this treatment anytime soon. Having said that – there is great potential here.

To understand how this new approach works, let’s review some basics of immunity. (Note – the immune system is incredibly complex, and I can only give a very superficial summary here, but enough to understand what’s going on.) Mammalian immune systems have two basic components, innate immunity and adaptive immunity. The adaptive immune system is probably what most people think about when they think about the immune system and vaccines. Adaptive immunity targets and recognizes specific antigens (such as proteins) on pathogens like viruses, bacteria, or fungi. Antibodies attach to these antigens, flagging them to be targeted by immune cells like macrophages which then eat them. The macrophages in turn display the antibody-flagged antigens on their surface, triggering a greater and more specific reaction to those specific antigens. Adaptive immunity is considered slow (it takes days to ramp up), specific (it targets specific antigens on specific pathogens) and durable (it has memory, and will react more quickly and robustly to the same pathogen in the future).

By contrast, the innate immune system is fast, non-specific, and short-lived with no memory. The innate immune system consists of physical barriers, like skin and mucosa, and immune cells that target pathogens based on broad patterns that are not learned but are innate (hence the name). There are Toll-like receptors (TLRs – the name Toll comes from the German for “fantastic”, allegedly said by a researcher upon discovery). The Toll gene was first discovered in fruit flies and then similar genes were later discovered in mammals, hence “Toll-like”. TLRs detect pathogen-associated molecular patterns (PAMPs), which are highly conserved features of types of pathogens. In other words –  a TLR might recognize a snippet of RNA as a pattern typical of RNA viruses, or proteins that tend to occur on pathogenic bacteria. “That looks like an RNA virus, so let’s attack it.”

While these are distinct and complementary parts of the immune system, they are also highly tied together. Components of the innate immune system trigger the adaptive immune system, which in turn stimulates innate immunity. In fact, many traditional vaccines contain adjuvants which stimulate innate immunity in order to boost adaptive immunity.

The new vaccine (technical name – GLA-3M-052-LS+OVA), which is a nasal spray given in three doses to the mice being studied, stimulated innate immunity, not adaptive immunity. Normally, after exposure to a pathogen or even allergen, innate immunity will be heightened for a few days, then return to normal. The nasal vaccine extends this heightened innate immunity in the lungs and respiratory system for three months. It does this by containing synthetic molecules that bind to TLRs, tricking them into responding as if a pathogen is present. The vaccine also contains a protein called ovalbumin, which stimulated T-cells of the adaptive immune system, keeping them resident in the tissue. These T-cells help maintain the heightened state of activity of the innate immune system. According to the authors: “Protection was mediated by persistent ovalbumin-specific CD4+ and CD8+ memory T cells that imprinted alveolar macrophages (AMs), enhancing antigen presentation and antiviral immunity.”

The trick of stimulating innate immunity was partly borrowed from the tuberculosis BCG vaccine, which also works by both triggering adaptive immunity but also stimulating the innate immune system. Researchers studies how the BCG vaccine accomplished this and applied that knowledge to this new vaccine.

In the study the researchers compared mice treated with three doses of the nasal vaccine to untreated mice and found that the treated mice were protected for at least three months from “SARS-CoV-2 and Staphylococcus aureus. In addition, the vaccine protected mice from other viruses (SARS-CoV-2, SARS, SCH014 coronavirus), bacteria (Acinetobacter baumannii), and allergens.”

In the best-case-scenario where this vaccine technology is safe and effective in people, what can we expect? Well, I don’t think this would replace any traditional vaccines based on adaptive immunity. Like the two halves of the immune system itself, it will likely be complementary to traditional vaccines. Traditional vaccines can provide years and sometimes decades of specific protection from common pathogens, and there is no substitute for that. Also, this vaccine works on respiratory infections only, although it may be possible to adapt this approach to other types of infection.

What an innate immunity-based vaccine provides is a good first line of defense against an outbreak, epidemic, or seasonal infection. This would require many millions of doses (or even billions, in the context of a pandemic) being available at short notice to provide several months of resistance to an entire population at the beginning of an outbreak or a seasonal infection (like the flu). It remains to be seen if this vaccine reduces the risk of spread or just the severity of infection. If it reduces spread (which is plausible, if viruses, for example, don’t have a chance to reproduce in large numbers), it could short circuit many respiratory epidemics.

Imagine if this vaccine were available at the beginning of COVID. It could have provided significant protection, reducing death and morbidity, and allowed us time to study the virus and develop adaptive vaccines. That is one of the benefits – it provides broad spectrum non-specific defense. We don’t necessarily need to know anything about the pathogen for this vaccine to work, so it is ideal for novel respiratory outbreaks. It also means we don’t need to track new strains of a virus, and that pathogens cannot easily adapt to this immunity by simply mutating their proteins.

There is a lot of research ahead to study the safety and effectiveness of this vaccine in humans. Even once a vaccine is approved, more research is needed to study long term effectiveness and potential side effects. One thing to consider, for example – there is likely a reason that evolutionary forces did not favor us having our innate immunity on high alert at all times. There is often a downside to immune activity, which is mostly why you feel like crap during an infection. It’s not the bug, it’s your bodies reaction to the bug. The worst-case scenario is that this approach increases the risk of auto-immunity.

Having said that – we are not living in the world in which we evolved. We are living in a globally connected world of over 8 billion people, often in close proximity to potential animal reservoirs of pathogens. The selective pressures are likely now different than they were when we were living in largely isolated tribes. But we don’t have to wait for evolution to work its slow grim task, we can tweak our immune systems with science and technology to provide some enhanced protection when and where we need it.

The post Universal Respiratory Vaccine first appeared on NeuroLogica Blog.

Nearly all of the solar system’s planets are about to file across the night sky in a planetary alignment, and it will be visible from anywhere on Earth

When a trial has results that defy basic biology, it's reasonable to be skeptical.

The post Implausible Apple Cider Vinegar Weight Loss Study Retracted first appeared on Science-Based Medicine.

The UK's first geothermal plant in Cornwall is part of a wave of projects aiming to meet growing electricity demand, some of them enabled by technology from oil and gas fracturing

Both boosters and sceptics have strongly held opinions on AI tools like ChatGPT, but after an experiment in vibe coding, I have realised that both camps are wrong, says Jacob Aron

The existence of massive, elliptical galaxies in the early universe has puzzled astronomers for two decades. An international team led by Nikolaus Sulzenauer and Axel Weiß from the Max Planck Institute for Radio Astronomy (MPIfR) used data from the Atacama Large Millimeter/submillimeter Array (ALMA) to shed light on this open question of galaxy formation. They studied one of the most spectacular galaxy aggregations in great detail and published their results in the current issue of The Astrophysical Journal.