TESS, the Transiting Exoplanet Survey Satellite has been on the lookout for alien worlds since 2018. It has just hit the news again having identified an extreme triple star system where two stars orbit each other every 1.8 days. The third component circles them both in 25 days – this puts the entire system within the orbit of Mercury with a little wriggle room to spare! To visual observers, it looks like a single star but the power of TESS revealed a flicker as the stars line up and pass one another along our line of sight. Eventually, the two inner stars will merge, triggering a supernova event!
Exoplanets are planets in orbit around other star systems. Unlike the familiar planets in our own Solar System, their size and composition varies widely. To date gas giants larger than Jupiter have been found and small rocky worlds similar to Earth have been spotted. The techniques to hunt down the alien worlds vary from the transit method to the radial velocity method which detects a star’s wobble caused by the presence of a planet. Using these various different techniques, over 5,000 exoplanets have been identified.
“Icy and Rocky Worlds” is a new exoplanet infographic from Martin Vargic, an artist and space enthusiast from Slovakia. It’s available as a wall poster on his website. Image Credit and Copyright: Martin Vargic.TESS was launched by NASA in April 2018 with the purpose of hunting down exoplanets. It uses the technique that relies upon searching for transit events as planets cross the face of their host star. Since it began operations, TESS has monitored the brightness of over 200,000 stars looking for tiny dips in brightness. It’s been particularly focussed on looking for Earth sized planets orbiting within a stars habitable zone. Here the conditions are such that a planet could support liquid water and therefore may harbour life.
Illustration of NASA’s Transiting Exoplanet Survey Satellite. Credit: NASA’s Goddard Space Flight CenterIn an exciting twist to the usual approach for hunting exoplanets, a team of professional and amateur astronomers have joined forces with artificial intelligence and found a strange new multiple star system. Called TIC 290061484 it consists of twin stars orbiting each other every 1.8 days and a third star that orbits them both in just 25 days. The discovery beats the existing record for the shortest outer orbital period of a stellar system that was set in 1956 by 8 days!
The edge-on presentation of the system is perfectly aligned for analysis. Monitoring the movement and brightness changes it is possible to measure orbits, masses, sizes and temperatures of the stellar components. The team, led by Veselin Kostov from NASA’s Goddard Space Flight Center published their findings in the Astrophysical Journal.
Using TESS’ sensitivity to pickup flickering and brightness changes, the nature of the triple star system was revealed. Located in the constellation Cygnus almost 5,000 light years away the team monitored the dips in brightness as one star passed in front of the other. Using the capability of AI and machine learning, the team were able to filter the immense amounts of data to identify dimming events from transits rather than just the flicking of light caused by our own atmosphere.
The data was then analysed by teams of citizen scientists who had formed ‘The Planet Hunters’ in 2010 to support exoplanet surveys. They later joined forces with professional astronomers as ‘the Visual Survey Group’ where they would provide real visual assessment of survey results. The team have now developed the model for the system and even forecast that, in between 20 to40 million years, the inner stars will expand and trigger a supernova explosion.
The hunt is now on for more close multiple star systems with the Nancy Grace Roman Space Telescope (NGRST) joining the hunt. With its far higher resolution, NGRST will offer 36,000 pixels where TESS only offered 1, giving a new window on the same region of the Galaxy.
Source : NASA’s TESS Spots Record-Breaking Stellar Triplets
The post TESS Finds a Triple Star System that Could Fit within Mercury’s Orbit appeared first on Universe Today.
I’m going to do something I rarely do and make a straight-up prediction – I think we are close to having AI apps that will function as our all-purpose digital assistants. That’s not really a tough call, we already have digital assistants and they are progressing rapidly. So I am just extending an existing trend a little bit into the future. My real prediction is that they will become popular and people will use them. Predicting technology is often easier than predicting public acceptance and use (see the Segway and many other examples.) So this is more of a risky prediction.
I know, for those who lived through the early days of personal computers, if you mention “personal digital assistant” the specter of “Clippy” immediately comes to mind. Such assistants can be intrusive and annoying. That has something to do with the fact that they are intrusive and annoying, coupled with the fact that they are not that useful. Siri and similar apps are great for a few things – acting as a verbal interface for Google searchers or serving up music, or basic functions like setting an alarm on your phone. But I am talking next level. Siri is to the AI-fueled assistants I am talking about as the PDAs of the 80s and 90s are to the smartphones of today.
With that analogy I am getting into real tricky prediction territory – predicting a transformative or disruptive technology. This is the kind of technology that, shortly after using it regularly you lose the ability to conceive of life without it. Nor would you want to go back to the dark days before your life was transformed. Think microwave, the ability to record and play pre-recorded content for TV, the web, GPS, and the smartphone. This is what Segway wanted to be.
Clearly I am thinking of some idealized version of a personal AI assistant, and I am. But there is no reason we can’t get there. All the elements are already there, someone just has to put it all together in a functional and pretty package (like the iPhone). Microsoft thinks we are one year away from such an application, and clearly they are planning on being the ones to bring it to market. They will likely have competition.
Let’s think first about what a personal AI assistant can be in that idealized form, and then consider the potential downsides. I am envisioning an app that lives on multiple of your electronic devices – your phone, tablet, laptop and desktop. It uses all the devices you do and is always there for you. You can interact with it by voice or text. It has access to whatever information you give it access to, such as your calendar, contact list, accounts, passwords, and digital assets. And essentially it can do anything you want within those digital contents at a command. It can manage your schedule, take the initiate to remind you about upcoming appointments or deadlines, and schedule new events.
Further, it can sift through your e-mail, getting rid of spam, warning about dangerous e-mails, organizing the rest by priority or whatever scheme you wish, even respond to some e-mails automatically or by your command. It can interact with all your other apps – “Find the quickest route to my destination, load it up into GPS, and remind me 10 minutes before I have to leave.” Or you can tell it to prepare a summary for you on some topic, after searching the web for the latest information. It can manage your computer hygiene – “Your anti-spyware software is out of date, and there is a notice of a virus coming you are not protected from. Shall I download and install the update?” You can tell it to always download and install security updates without asking first. Yes – Windows can already to this, for Windows, but not third party apps.
A feature I would love to see – find me flights with these parameters, or you could tell it to book you a hotel, rental car, or anything. It knows your preferences, your frequent flyer numbers, your seating preferences, and which airports you prefer. Or you could ask it to find 20 gift options for Mother’s Day.
What will make an AI assistant better than anything that has come before (using the new AI tech) is that it can remember all of its interactions with you and learn. Over time, it becomes more and more personalized. It will know when not to disturb you, for example. It will learn to become less annoying and more helpful, as you learn how best to leverage this technology. This kind of tech has the potential to relieve a significant amount of the digital drudgery that we have foisted upon ourselves. I know some people will say – just disconnect. But that is not a viable option for many people, and we should not have to surrender all the benefits of computers simply to avoid that drudgery.
What about the downsides? The biggest potential weakness is that such apps will just suck. They won’t do their jobs well enough to reduce your digital burden. They can also be a security risk, if they have access to all your personal information. Security would need to be an iron-clad feature of such apps. They can also just get information wrong. This is a universal problem with the latest crop of AI, the so-called hallucinations. But this is something the industry is working on and it is getting better. It’s also less of a problem with focused (rather than open-ended) tasks.
There will eventually also be some optional features that some people will want in such an app, such as personal AI counseling or life-coaching. This can have different levels. At its most basic level, the AI can be just a rational friend who is a good listener, and gives really basic time-tested and expert-approved advice. It can function as a first-level counselor who is always there for you, and remembers all your previous conversations. You can select its personality, and level of intrusiveness. You may be able to have certain optional “nag” settings, such as keeping you on that diet, or reminding you not to be too sarcastic. It could make you more thoughtful, reminding you of all the social niceties that often slip through the cracks of our busy lives.
Then there will be those features that I am not thinking of, but that someone will think of when you have hundreds or even thousands of companies competing with each other and using feedback from billions of users. There may also be negative unintended consequences, and culture wars about social engineering. We will have to see how it all shakes out.
But I stick by my prediction – the potential of relieving us of digital drudgery and all the potential value-added of such an AI assistant – when it works really well – is just too great. I do think this will be like the next smartphone. We will probably know soon enough.
Note: I suspect the comments will fill with people giving examples of how the various pieces of this functionality already exists. I know, and I use a lot of them. You can cobble together password managers, an app to go through your photos, a schedule reminder, and e-mail sorters. Individual applications of a smartphone also predated the smartphone. The power was having everything in one device. Same here – one AI to bring it all together and add new functionality.
The post AI Copilots Are Coming first appeared on NeuroLogica Blog.
A busy news week: a Nobel prize, another chance of auroras, and… a comet. It’s probably not the comet of the century, but comets like this one show up only about once every ten years. This one has already been visible in early morning skies. This week it enters our evening skies, and will likely be a lovely sight after dark for the rest of October.
Thursday, Friday and Saturday this week, immediately after sunset and just to the right and above the Sun, comet A3 MAY be at its most spectacular. BE READY! You will need a low and rather flat horizon, and you have less than an hour to see it before it sets, too.
Day by day, the comet will move up and to the left, beginning at the Sun’s right. Look there once the Sun is significantly below the true horizon and the sky has darkened a bit.Later in the month it will be visible longer into the evening, but much less bright.
What is a comet? Its core (or “nucleus”) is a large ball of ice and dust, perhaps 20 miles [40 kilometers] across, traveling on an orbit of the Sun and moving through the solar system among the planets. That core is far too small and far away to see. But when the comet approaches the Sun, the Sun heats the core, which throws off dust and gas that is blown by the solar wind into a big cloud around the core and into huge trails that stretch tens of millions of miles [km]. These trails reflect sunlight, and can be seen from Earth despite being millions of miles [km] away.
Please do not confuse this comet with Earth’s temporary second moon, which has gotten a ridiculous amount of overheated press, causing both distraction and confusion. Here’s how this itty-bitty “moonlet” compares with comet A3.
The last bullet point is the most important. Moonlet is of intellectual interest only; there’s absolutely nothing to see, despite the crazed news stories in the media. Comet A3 might turn out to be one of the better celestial objects to see in a lifetime. Get the word out!
Can dogs be taught to speak intelligently using floor buttons that represent words?
Every second in the Universe, more than 3,000 new stars form as clouds of dust and gas undergo gravitational collapse. Afterward, the remaining dust and gas settle into a swirling disk that feeds the star’s growth and eventually accretes to form planets – otherwise known as a protoplanetary disk. While this model, known as the Nebular Hypothesis, is the most widely accepted theory, the exact processes that give rise to stars and planetary systems are not yet fully understood. Shedding light on these processes is one of the many objectives of the James Webb Space Telescope (JWST).
In a recent study, an international team of astronomers led by University of Arizona researchers and supported by scientists from the Max Planck Institute of Astronomy (MPIA) used the JWST’s advanced infrared optics to examine protoplanetary disks around new stars. These observations provided the most detailed insights into the gas flows that sculpt and shape protoplanetary disks over time. They also confirm what scientists have theorized for a long time and offer clues about what our Solar System looked like roughly 4.6 billion years ago.
The research was led by Ilaria Pascucci, a Professor of astrophysics and planetary science from the Lunar and Planetary Laboratory (LPL) at The University of Arizona. She was joined by researchers from the Space Telescope Science Institute (STScI), the Observatoire de Paris, the National Optical-Infrared Astronomy Research Laboratory (NOIRLab), the Carl Sagan Center at the SETI Institute, the Max-Planck-Institute for Astronomy, and multiple universities. The paper that describes their findings recently appeared in Nature Astronomy.
Artist’s impression of a young star surrounded by a protoplanetary disk made of gas and dust. Credit: LMU/Thomas Zankl, crushed eyes mediaIn order for young stars to grow, they must draw in gas from the protoplanetary disk surrounding them. For that to happen, the gas must lose angular momentum (inertia); otherwise, it would consistently orbit the star and never accrete onto it. However, the mechanism that allows this to happen has remained the subject of debate among astronomers. In recent years, magnetically driven disk winds have emerged as a possible mechanism. Primarily powered by magnetic fields, these “winds” funnel streams of gas away from the planet-forming disk into space at dozens of kilometers per second.
This causes it to lose angular momentum, allowing the leftover gas to fall inward toward the star. For their study, the researchers selected four protoplanetary disk systems that appear edge-on when viewed from Earth. Using Webb’s Near Infrared Spectrograph (NIRSpec), the team could trace various wind layers by tuning the instrument to detect distinct atoms and molecules in certain transition states. The team also obtained spatially resolved spectral information across the entire field of view using the spectrograph’s Integral Field Unit (IFU).
This allowed the team to trace the disk winds in unprecedented detail and revealed an intricate, three-dimensional layered structure: a central jet nested inside a cone-shaped envelope of winds at increasing distances. The team also noted a pronounced central hole inside the cones in all four protoplanetary disks. According to Pascucci, one of the most important processes at work is how the star accretes matter from its surrounding disk:
“How a star accretes mass has a big influence on how the surrounding disk evolves over time, including the way planets form later on. The specific ways in which this happens have not been understood, but we think that winds driven by magnetic fields across most of the disk surface could play a very important role.”
However, other processes are also responsible for shaping protoplanetary disks. These include “X-wind,” where the star’s magnetic field pushes material outward at the inner edge of the disk. There are also “thermal winds,” which blow at much slower velocities and are caused by intense starlight eroding its outer edge. The high sensitivity and resolution of the JWST were ideally suited to distinguish between the magnetic field-driven wind, the X-wind, and the thermal wind. These observations revealed a nested structure of the various wind components that had never been seen before.
Observed gas jet and wind structure of the HH 30 protostar, with offsets given in astronomical units (au), the mean distance between the Sun and Earth. Credit and ©: I. Pascucci et al./MPIAA crucial distinction between the magnetically driven and the X-winds is how they are located farther out and cover broader regions. These winds cover regions that correspond to the inner rocky planets of our solar system, roughly between Earth and Mars. They also extend farther above the disk than thermal winds, reaching hundreds of times the distance between Earth and the Sun. While astronomers previously found observational evidence of these winds based on interferometric observations at radio wavelengths, they could not image the full disk in detail to determine the winds’ morphology.
In contrast, the new JWST observations revealed a nested structure and morphology that matched what astronomers anticipated for magnetically driven disk wind. Looking ahead, Pascucci’s and her team hope to expand these observations to more protoplanetary disks to see how common the observed disk wind structures are and how they evolve.
“Our observations strongly suggest that we have obtained the first detailed images of the winds that can remove angular momentum and solve the longstanding problem of how stars and planetary systems form,” she said. “We believe they could be common, but with four objects, it’s a bit difficult to say. We want to get a larger sample with JWST and then also see if we can detect changes in these winds as stars assemble and planets form.”
Further Reading: MPIA, Nature Astronomy
The post The JWST Reveals New Things About How Planetary Systems Form appeared first on Universe Today.
China have a roadmap to sent astronauts to the Moon in 2030 and when they do, they are going with a very definite nod to the Chinese origins to the rocket! Their officials have unveiled the new look Chinese space suit with all the mod cons but with a design that is somewhat reminiscent of Chinese armour. There will some fabulous features like the close and long distance field of view visor, a chest control panel and a protective material to shield against the harmful lunar environment.
Think of space exploration and it won’t be long before images of astronauts in space suits appears in your mind. The puffy looking outfits are of crucial importance to human space flight for they are the life-support system, enabling an astronaut to stay alive in space! Providing protection against extreme temperatures, the suit is also able to maintain a constant pressure around the astronaut to protect from the vacuum of space.
Astronaut Samantha Cristoforetti – Image : NASAThey provide oxygen for breathing, a coolant system, toiletry provision and a helmet with a special sun visor to protect their eyes. It’s fair to say, without a spacesuit, space exploration wouldn’t be possible, at least outside the confines of a spaceship.
Just recently, the China Manned Space Agency (CMSA) revealed their space suit to be used in the first China Moon landing. It was displayed at the third Spacesuit Technology Forum in the southwest Chongqing Municipality and was adorned with red stripes. The stripes on the arms are a nod to the famous ‘flying apsaras’ (the flying celestial beings that accompany Buddhas!) while the stripes on the legs represent rocket flames during launch!
A video has been released that shows the space suits being put through their paces by astronauts Zhai Zhigang and Wang Yaping. It shows the duo wearing the space suits and performing a range of different movements from walking, bending, kneeling on one knee and squatting. All of which seems to have been performed with ease.
The two made Chinese history when Zhia became the first Chinese astronaut to conduct a spacewalk and Wang became the first woman who entered the Chinese space station.
Tiangong Chinese space station Image Credit: China Manned Space Agency.The new suit began development in 2020 with the aim to produce a lightweight suit for lunar exploration that was compact and reliable. To enable the success, a number of technological breakthroughs was achieved. The first and second generations of the Feitian spacesuits which preceded this new design have enabled 17 astronauts to complete 17 extravehicular activities (activities outside the space craft) helping construct and maintain the Tiangong Space Station.
With all going to plan, the Chinese lunar mission plan is to land an explorer on the Moon’s surface by 2030. With the launch (pardon the pun) of the new Moon-landing spacesuit, CSMA mark a new era in their shot for the Moon.
Source : China unveils moon-landing spacesuit for the first time
The post China Unveils its Lunar Spacesuit appeared first on Universe Today.
Mining the Moon to extract its resources is a critical step on humanity’s path into the solar system. One of the most common resources on the Moon is considered relatively valuable here on Earth – titanium. At $10,000 a ton, it is one of the more valuable metals used in various industries, such as aerospace and nanotechnology. So, could we utilize titanium from the Moon to supply Earth’s economy with more of this valuable material? That question is the focus of a paper from researchers at Uppsala University in Finland.
It should come as no surprise that titanium, the universe’s ninth most common element, is abundant on the Moon. Most of the Moon’s titanium is contained in a mineral called ilmenite, which is also available on the Earth for only about $390 per metric ton. Ilmenite makes up as much as 20% of the volume of some rocks in the Sea of Tranquility, where the Apollo astronauts landed and collected samples.
To ensure they accurately represented the amount of potential titanium available at this location on the Moon, the authors, Renaud Merle, Mikael Höök, Valentin Troll, and Alexander Giegling, examined two different concentrations of ilmenite—3% for the general regolith in the area and 15% for the basaltic rocks the Apollo astronauts sampled. They then compared the potential output of a mine in this region to the Tellnes mine in their native Norway, one of the world’s most productive.
Fraser interview Dr. Phil Metzger – one of the foremost experts on mining the lunar surface.Tellnes sits on top of one of the richest deposits of titanium in the world, with an estimated 575 million metric tons available for mining. While it is dwarfed in size by the scale of the Sea of Tranquility, its high concentration of 18% of TiO2 (titanium dioxide – the most commonly found form of the material) means it arguably has a high lifetime output and a baseline for comparing the output of a lunar mine. Importantly, it regularly produces 750 kilotons of ilmenite annually, representing about 5% of worldwide titanium production.
Operating the mine requires a large excavator and six large dump trucks. Overall, the excavator and dump trucks manufactured by Caterpillar represent almost 2,500 tons of material to be shipped to the Moon. The authors estimate that would require more than 40 launches of a Saturn V—about equivalent to how many it has taken to build the ISS fully.
Once the equipment is on the Moon, it must still be powered. Large diesel engines that currently power these mammoth machines aren’t really an option on the Moon. On Earth, the total power required to operate all seven machines is about 11 MW, which the authors think could be met by a combination of solar energy and nuclear power. However, they don’t mention how a large enough battery would affect their weight calculations.
Isaac Arthurs discusses the benefits of mining the Moon.So, how effective would such a mining operation be if everything was in place, powered up, and running? There are several ways to measure effectiveness, but first, let’s look at the total amount of titanium produced. The authors’ calculations put the expected mined rate at about 500 kt per year—about 2/3rds the amount of Tellnes’ output—but it should be noted that it will take up to 20 years to scale up to this level.
A lot can change in 20 years in terms of technology and material usage more generally, so ultimately, this paper doesn’t make a convincing case for why it would be beneficial to mine titanium as an economical solution, especially since mines on Earth could quickly scale up their production to meet increased Earth-bound demand.
However, the mining process does have an added advantage—breaking apart ilmenite to release the titanium also releases oxygen, which is necessary for everything from rocket fuel to breathable air. So, instead of going after the titanium specifically, early lunar mining efforts might focus on the oxygen contained in the ilmenite and produce titanium—ostensibly the more valuable of the two materials back on Earth—as a side effect.
A closeup of a titanium lattice ball made using a 3-D printer. According to the European Space Agency, the hollow spheres have a “complex external geometry” that cannot be made with the usual manufacturing processes.However, as the authors point out in the paper, it is doubtful that any such project would be undertaken in the next ten years. Until then, technologies will continue to develop until someday, someone will mine the first bit of titanium off the Moon. It just remains to be seen where this valuable material will be most useful once that happens.
Learn More:
Merle et al. – Assessing the plausibility of mining lunar titanium
UT – Researchers Developed a Test Bed For Separating Valuable Material on the Moon
UT – Finally, an Explanation for the Moon’s Radically Different Hemispheres
UT – The Moon Might Be More Metal-Rich Than We Thought
Lead Image:
A lunar mining facility harvests oxygen from the resource-rich volcanic soil of the eastern Mare Serenitatis.
Credit: NASA/Pat Rawlings
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The European Space Agency’s Hera spacecraft is on its way to do follow-up observations of Dimorphos, two years after an earlier probe knocked the mini-asteroid into a different orbital path around a bigger space rock.
Scientists say the close-up observations that Hera is due to make millions of miles from Earth, starting in 2026, will help them defend our planet from future threats posed by killer asteroids.
“Hera’s ability to closely study its asteroid target will be just what is needed for operational planetary defense,” Richard Moissl, who heads ESA’s Planetary Defense Office, said today in a news release. “You can imagine a scenario where a reconnaissance mission is dispatched rapidly, to assess if any follow-up deflection action is needed.”
The car-sized probe lifted off from Cape Canaveral Space Force Station in Florida atop a SpaceX Falcon 9 rocket at 10:52 a.m. ET (14:52 UTC) today, just as Hurricane Milton was approaching from the Gulf of Mexico. The day before the launch, forecasters put the chances of acceptable weather at just 15 percent. Nevertheless, SpaceX persisted.
Due to the mission’s requirements, the first-stage booster couldn’t be recovered this time, as has become the norm for Falcon 9 missions. This was the booster’s 23rd and final mission. A little more than an hour after liftoff, the rocket’s second stage put Hera on its interplanetary trajectory.
During the spacecraft’s two-year cruise to Dimorphos, it’s due to execute a series of course-changing maneuvers, including a swing past Mars that will provide an opportunity for observations of Deimos, one of the Red Planet’s moons.
View from Falcon 9's second stage during the Hera mission pic.twitter.com/a4Qrgg6Pp6
— SpaceX (@SpaceX) October 7, 2024Hera is returning to the scene of a cosmic crash in 2022 between Dimorphos — which is about 530 feet across, or the size of the Great Pyramid in Egypt — and NASA’s Double Asteroid Redirection Test spacecraft, or DART.
DART was intentionally sent to a collision with Dimorphos to gauge the impact’s effect on the asteroid’s orbit around a larger asteroid known as Didymos. After the crash, scientists determined that Dimorphos’ orbital period had been shortened by 33 minutes, which represented a reduction of roughly 5%. They also identified a plume of debris that extended thousands of miles into space.
Hera is designed to conduct a more detailed “crash scene investigation,” providing data about Dimorphos’ shape and composition as well as the characteristics of the crater left behind by the smash-up.
The spacecraft will deploy two nanosatellites to aid in the investigation: One of the CubeSats, known as Milani, will survey the makeup of Dimorphos and the dust that surrounds it. Meanwhile, the Juventas mini-satellite will perform the first-ever subsurface radar probe of an asteroid. In the later phases of its six-month survey, Hera will test out an experimental self-driving mode as it navigates around Didymos and Dimorphos autonomously.
Data about the aftereffects of DART’s crash will be factored into the plans for deflecting the orbital paths of asteroids, if those paths are ever found to pose a substantial threat of a collision with Earth. Such strategies might require taking action years in advance of an encounter.
“By the end of Hera’s mission, the Didymos pair should become the best-studied asteroids in history, helping to secure Earth from the threat of incoming asteroids,” said Hera mission scientist Michael Kueppers.
What is ESA's #HeraMission? We currently know of more than 35 000 asteroids that come close enough to Earth for us to keep an eye on. Hera is part of the international effort to answer the question: could we do anything if we spotted one on a collision course? pic.twitter.com/MwgQmv7bZK
— ESA's Hera mission (@ESA_Hera) October 7, 2024The post Hera Probe Heads Off to See Aftermath of DART’s Asteroid Impact appeared first on Universe Today.
Two Americans, Gary Ruvkun of Massachusetts General Hospital and Harvard University, and Victor Ambrose of the University of Massachusetts Medical School, have split this year’s Nobel Prize in Physiology or Medicine for the discovery of microRNAs (miRNAs), single-stranded bits of RNA that do not code for proteins but act to regulate other genes. The Nobel organization’s press release explains the significance of the discovery, but you can read the whole thing, which is much longer than this:
This year’s Nobel Prize honors two scientists for their discovery of a fundamental principle governing how gene activity is regulated.
The information stored within our chromosomes can be likened to an instruction manual for all cells in our body. Every cell contains the same chromosomes, so every cell contains exactly the same set of genes and exactly the same set of instructions. Yet, different cell types, such as muscle and nerve cells, have very distinct characteristics. How do these differences arise? The answer lies in gene regulation, which allows each cell to select only the relevant instructions. This ensures that only the correct set of genes is active in each cell type.
Victor Ambros and Gary Ruvkun were interested in how different cell types develop. They discovered microRNA, a new class of tiny RNA molecules that play a crucial role in gene regulation. Their groundbreaking discovery revealed a completely new principle of gene regulation that turned out to be essential for multicellular organisms, including humans. It is now known that the human genome codes for over one thousand microRNAs. Their surprising discovery revealed an entirely new dimension to gene regulation. MicroRNAs are proving to be fundamentally important for how organisms develop and function.
And here’s how it started: as so often, with a seemingly minor observation that blew up big time, leading to generalizations about control of gene expression in all organisms—even viruses (but not bacteria).
In the late 1980s, Victor Ambros and Gary Ruvkun were postdoctoral fellows in the laboratory of Robert Horvitz, who was awarded the Nobel Prize in 2002, alongside Sydney Brenner and John Sulston. In Horvitz’s laboratory, they studied a relatively unassuming 1 mm long roundworm, C. elegans. Despite its small size, C. elegans possesses many specialized cell types such as nerve and muscle cells also found in larger, more complex animals, making it a useful model for investigating how tissues develop and mature in multicellular organisms. Ambros and Ruvkun were interested in genes that control the timing of activation of different genetic programs, ensuring that various cell types develop at the right time. They studied two mutant strains of worms, lin-4 and lin-14, that displayed defects in the timing of activation of genetic programs during development. The laureates wanted to identify the mutated genes and understand their function. Ambros had previously shown that the lin-4 gene appeared to be a negative regulator of the lin-14 gene. However, how the lin-14 activity was blocked was unknown. Ambros and Ruvkun were intrigued by these mutants and their potential relationship and set out to resolve these mysteries.
After his postdoctoral research, Victor Ambros analyzed the lin-4 mutant in his newly established laboratory at Harvard University. Methodical mapping allowed the cloning of the gene and led to an unexpected finding. The lin-4 gene produced an unusually short RNA molecule that lacked a code for protein production. These surprising results suggested that this small RNA from lin-4 was responsible for inhibiting lin-14. How might this work?
Here’s the announcement, which I always find exciting:
AND THE TWO CONTESTS:
1.) Guess who will win the other two Nobel Prizes in science: Physics and Chemistry. One guess per discipline, and the first person who guesses both winners gets one of my trade books, autographed per their choice (including cat drawings).
2.) Alternatively you can choose the other contest: Guess who will win these two prizes: Literature and Peace. Same rules as above, and same prize.
You can guess in only one of these two competitions.
In previous years, people have failed miserably in these contests, but someday someone will win. . . .