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A look at recent studies finding leaded gasoline caused 151 million mental health illnesses in the United States.

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"RFK Jr. switching sides on vaccines now is like an arsonist urging people to put out the fire he started."

The post RFK Jr.: Vaccines Not Only Protect Individual Children From Measles, But Also Contribute To Community Immunity first appeared on Science-Based Medicine.

For decades, scientists have relied on electrodes and dyes to track the electrical activity of living cells. Now, engineers have discovered that quantum materials just a single atom thick can do the job with high speed and resolution -- using only light.

For decades, scientists have relied on electrodes and dyes to track the electrical activity of living cells. Now, engineers have discovered that quantum materials just a single atom thick can do the job with high speed and resolution -- using only light.

Researchers have developed an innovative tool that enhances surgeons' ability to detect and remove cancer cells during cryosurgery, a procedure that uses extreme cold to destroy tumors. This breakthrough technology involves a specialized nanoscale material that illuminates cancer cells under freezing conditions, making them easier to distinguish from healthy tissue and improving surgical precision.

A new study sheds light on ventilator-induced lung injury, a complication that gained increased attention during the COVID-19 pandemic, which led to a surge in patients requiring mechanical ventilation. The study suggests that repeated collapse and reopening of tiny alveoli -- air sacs in the lungs essential for breathing -- during mechanical ventilation may cause microscopic tissue damage, playing a key role in ventilator-related injuries that contribute to thousands of deaths annually.

DARPA scientists are exploring ways to grow massive biological objects, such as telescope antennas or huge nets to snag debris, in space

Quantitative phase imaging (QPI) is a microscopy technique widely used to investigate cells and tissues. Even though first biomedical applications based on QPI have been developed, both acquisition speed and image quality need to improve to guarantee a widespread reception. Scientists suggest leveraging an optical phenomenon called chromatic aberration -- that usually degrades image quality -- to produce suitable images with standard microscopes.

A research team has developed a three-dimensional neural electrode that deforms smoothly using soft actuation technology. It is expected to be used in various next-generation soft bioelectronic devices, including electroceuticals for peripheral nerve treatment.

Glaucoma is called the 'silent thief of sight' as many don't notice until significant, irreversible vision loss has already occurred. A revolutionary early screening tool using AI may stop this thief dead in its tracks.

A team of scientists has developed a method to illuminate the dynamic behavior of nanoparticles, which are foundational components in the creation of pharmaceuticals, electronics, and industrial and energy-conversion materials.

A decade of studies from labs around the world provide a growing evidence base that increasing the power of the brain's gamma rhythms could help fight Alzheimer's, and perhaps other, neurological diseases.

Distressing news and traumatic stories can cause stress and anxiety -- not only in humans, but these stories can also affect AI language models, such as ChatGPT. Researchers have now shown that these models, like humans, respond to therapy: an elevated 'anxiety level' in GPT-4 can be 'calmed down' using mindfulness-based relaxation techniques.

Scientists discover how defects in the surface of two-dimensional sheets alter ripple effects, even freezing the sheet's motion altogether.

As highly pathogenic H5N1 avian influenza continues to spread in the U.S., posing serious threats to dairy and poultry farms, both farmers and public health experts need better ways to monitor for infections, in real time, to mitigate and respond to outbreaks. Newly devised virus trackers can monitor for airborne particles of H5N1.

When a droplet of water falls on a hot pan, it dances across the surface, skimming on a thin layer of steam like a tiny hovercraft; this is known as the Leidenfrost effect. But now, researchers know what happens when a hot droplet falls on a cool surface. These new findings demonstrate that hot and burning droplets can bounce off cool surfaces, propelled by a thin layer of air that forms beneath them. This phenomenon could inspire new strategies for slowing the spread of fires and improving engine efficiency.

Researchers have published a new study showing an advanced new methane flare burner, created with additive manufacturing and machine learning, eliminates 98% of methane vented during oil production.

Pneumocystis jirovecii pneumonia (PJP) is the most common fungal pneumonia in children. But current diagnostic methods can take days an require an invasive bronchoscopy procedure. Now, a new CRISPR-based test has been developed to diagnose PJP more quickly and less invasively.

Here’s a new article in the Journal of Sexual Medicine that investigated the effects of gender-changing surgery on both males and females (over 18) with a diagnosis of gender dysphoria.  The results won’t make gender extremists happy, as in both cases rates of mental distress, including anxiety, and depression, were higher than those having surgery than those not having surgery after two years of monitoring. However, this doesn’t mean that the surgery shouldn’t be done, as the authors note that other studies show that people undergoing surgical treatment are, over the longer term, generally happy with the outcome.  The main lesson of the paper is that people who do undergo such surgeries should be monitored carefully for post-surgical declines in mental health.

Click the headline below to read.

The authors note that there are earlier but much smaller studies that show no decline in mental health after surgery, but these are plagued not only by small sample size, but also by non-representative sampling reliance on self-report, and failure to diagnose other forms of mental illness beyond gender dysphoria before surgery. The present study, while remedying these problems, still has a few issues (see below).

The advantages of this study over earlier ones is that the samples of Lewis et al. are HUGE, based on the TriNetX database of over 113 million patients from 64 American healthcare organizations. Further, the patients were selected only because they had a diagnosis of gender dysphoria and no record of any other form of mental illness (of course, it could have been hidden). Patients were divided into four groups (actually six, but I’m omitting two since they lacked controls): natal males with gender dyphoria who had or didn’t have surgery, and natal females with and without surgery. Here are the four groups, and I’ve added the sample size to show how much data they have:

• Cohort A: Patients documented as male (which may indicate natal sex or affirmed gender identity), aged ≥18 years, with a prior diagnosis of gender dysphoria, who had undergone gender-affirming surgery.

• Cohort B: Male patients with the same diagnosis but without surgery. [Cohorts A and B had 2774 patients.]

• Cohort C: Patients documented as female, aged ≥18 years, with a prior diagnosis of gender dysphoria, who had undergone gender-affirming surgery.

• Cohort D: Female patients with the same diagnosis but without surgery. [Cohorts C and D each had 3358 patients.]

A and B are the experimental and control groups for men, as are C and D for women.  Further, within each comparison patients were matched for sex, race, and age to provide further controls.  And here are the kinds of surgeries they had:

To be included, all patients had to be 18 years or older with a diagnosis of gender dysphoria, as identified by the ICD-10 code F64. This criterion was chosen based on literature highlighting elevated mental health concerns for transgender and nonbinary patients with gender dysphoria [15, 16]. Gender-affirming surgery cohorts consisted of patients with a documented diagnosis of gender dysphoria who had undergone specific gender-affirming surgical procedures. For transmen, this primarily included mastectomy (chest masculinization surgery, CPT codes 19 303 and 19 304), while for transwomen, this encompassed a range of feminizing procedures such as tracheal shave (CPT code 31899), breast augmentation (CPT code 19325), and vaginoplasty (CPT codes 57 335 and 55 970). These surgeries were identified using clinician-verified CPT codes within the TriNetX database, allowing for precise classification.

Note that there were a lot more “bottom” surgeries for trans-identifying men (as the authors call them, “transwomen”) than for trans-identifying women (“transmen”). Men prefer to change their genitals more often than women, even though, if you know how vaginoplasties are done, you have to be hellbent on getting one. (I don’t know as much about the results of getting a confected penis.)

I’ll be brief with the results: in both comparisons, those patients who had surgery had a significantly higher postsurgical risk of depression, anxiety, suicidal ideation, and substance abuse. But surgery had no effect on body dysmorphia: the obsession with flaws in one’s appearance.  Here are the tables and statistical comparisons of cohorts A vs. B and C vs. D, and the effect of surgery is substantial (results on women are similar though differences are smaller).  Some of the differences are substantial: anxiety in men, for example, was nearly five times higher in those who had surgery than those who did not.

As you see, there are significant differences for everything save body dysmorphia, for which there are no differences at all. The authors conclude that yes, at least over the two-year measurement period (again, mental states were monitored by professionals, and were not due to self report). Given that surgery does seem to improve well being over the long term, as the authors note twice, they conclude that the results provide more caution about taking care of patients who have transitional surgery:

The findings of this study underscore a pressing need for enhanced mental health guidelines tailored to the needs of transgender individuals following gender-affirming surgery. Our analysis reveals a significantly elevated risk of mental health disorders—including depression, anxiety, suicidal ideation, and substance use disorder—post-surgery among individuals with a prior diagnosis of gender dysphoria. Importantly, however, our results indicate no increased risk of body dysmorphic disorder following surgery, suggesting that these individuals generally experience satisfaction with their body image and surgical outcomes. Notably, the heightened risk of mental health issues post-surgery was particularly pronounced among individuals undergoing feminizing transition compared to masculinizing transition, emphasizing the necessity for gender-sensitive approaches even after gender-affirming procedures.

Possible problems. There are two main limitations of the study noted by the authors. First, individuals electing surgery may have higher levels of distress to begin with than those who didn’t, so the elevated rate of mental disorders in the surgery group could be artifactual in that way. Second, patients who have had surgery may be wealthier or otherwise have more access to healthcare than those who didn’t, and so higher rates of mental distress could result simply from a difference in detectability.

Now I don’t know the literature on long-term effects of surgery on well-being, so I’ll accept the authors’ statement that they are positive, even though patients with greater well being could, I suppose, still suffer more depression and anxiety. But those who are looking to say that there should be no surgery for those with gender dysphoria will not find support for that in this paper. What they will find is the conclusion that gender-altering surgery comes with mental health risks, and those must be taken into account. It’s always better, when dealing with such stuff. to have more rather than less information so one can inform those contemplating surgery.

Colorectal cancers will soon be the number one cause of cancer death among people under 50. Could changes in lifestyle and environment be to blame?