In a recent paper, a team of researchers indicated that photosynthetic bacteria could exist just beneath the snow and ice around Mars' mid-latitudes. If true, this could be the most easily accessible place to look for present-day life on Mars.
The solar system is currently embedded deep within the Local Bubble, a region of relatively low density stretching for a thousand light-years across. It was carved millions of years ago by a chain of supernova explosions. And the evidence for it is right under our feet.
According to a recent study by the non-profit Explore Titan, a nuclear-fission propulsion spacecraft could enable the first crewed mission to Titan, Saturn's largest moon.
In our neighborhood of the Milky Way, we see a region surrounding the solar system that is far less dense than average. But that space, that cavity, is a very irregular, elongated shape. What little material is left inside of this cavity is insanely hot, as it has a temperature of around a million Kelvin.