Genome editing has advanced at a rapid pace with promising results for treating genetic conditions -- but there is always room for improvement. A new paper showcases the power of scalable protein engineering combined with machine learning to boost progress in the field of gene and cell therapy. In their study, authors developed a machine learning algorithm -- known as PAMmla -- that can predict the properties of about 64 million genome editing enzymes. The work could help reduce off-target effects and improve editing safety, enhance editing efficiency, and enable researchers to predict customized enzymes for new therapeutic targets.
A new tissue expansion method enables scientists to use mass spectrometry imaging to simultaneously detect hundreds of molecules at the single cell level in their native locations.
Let’s turn the sun into a telescope. In fact, we don’t have to do any work – we just have to be in the right spot.
Studying the Sun is becoming increasingly important as more and more of our infrastructure moves off the surface and into the realm where coronal mass ejections and the solar wind can begin to affect them. Scientists recognize this problem and have started devoting more and more resources to studying the Sun, specifically the "space weather" that might affect us. Recently, one of the newest members of the group of satellites focused on studying the Sun hit a milestone when the Polarimeter to Unify the Corona and Heliosphere (PUNCH) mission took on its first light.
The game, called StarStarter, rewards players for directing their attention away from negative stimuli and towards positive ones
Planetary scientists have plenty of theories about Mars and its environmental past. Two of the most widely accepted are that there was a carbon dioxide atmosphere and, at one point, liquid water on Mars' surface. However, this theory has a glaring problem: Where should the rocks have formed from the interactions between carbon dioxide and water? According to a new paper by scientists at several NASA facilities using data collected by the rover Curiosity, the answer is right under the rover's metaphorical feet.
A huge colony of Pavona coral near the coast of Saudi Arabia is thought to be the largest living example found in the Red Sea
With the assumption that students are going to use artificial intelligence and large language models such as ChatGPT to do their homework, researchers set out to learn how well the free version of ChatGPT would compare with human students in a semester-long undergraduate control systems course.
Researchers introduced a novel method for fabricating functional flat-to-shape objects using a computer-controlled sewing machine. The team's method uses the sewing machine to stitch pockets between layers of fabric, and stiff panels are inserted into the pockets. Multiple fabrics types can be used, ranging from muslin for heavy-duty applications to more delicate fabrics for decorative purposes. The materials can also be customized on a panel-by-panel basis to adapt to each object's needs. The researchers demonstrated how the materials can be chosen to support a variety of functional goals, such as using thicker plywood for a human-weight supporting chair and custom LED panels with sheer fabric for a functional lamp. Additionally, The technique also allows for additional mechanisms such as cords, magnets, and hook-and-loop fasteners to direct and stabilize flat-to-shape transitions.
Researchers document a multi-faceted global snapshot of the environmental aspects and trends surrounding single-use plastics in a review article. The researchers state that the largest area of application for biodegradable plastic materials is the packaging segment, which accounts for about half of single-use plastic production.
Researchers have developed a light-induced DNA detection method that enables rapid, PCR-free genetic analysis. Their technique offers ultra-sensitive mutation detection in just five minutes, reducing costs and simplifying testing. The method has significant potential in healthcare, environmental conservation, and personal health monitoring.
Researchers explored a colloidal crystal model to produce specific polymorphs, required for use in materials science and pharmaceuticals.
Researchers have developed a new artificial intelligence (AI) technique that brings machine vision closer to how the human brain processes images. Called Lp-Convolution, this method improves the accuracy and efficiency of image recognition systems while reducing the computational burden of existing AI models.
Asymmetric interactions between molecules may serve as a stabilizing factor for biological systems. A new model reveals this regulatory role of non-reciprocity. The scientists aim to understand the physical principles based on which particles and molecules are able to form living beings and, eventually, organisms.
Financial benefits, such as saving on utility payments and avoiding electricity rate hikes, are a key driver of U.S. adults' willingness to consider installing rooftop solar panels or subscribing to community solar power, a new study suggests.
Researchers have made a breakthrough discovery that could potentially revolutionize treatments for antibiotic-resistant infections, cancer and other challenging gram-negative pathogens without relying on precious metals.
A planet 140 light-years from Earth is rapidly coming apart due to its close proximity to its star. The roasting planet is effectively evaporating away: It sheds an enormous amount of surface minerals as it whizzes around its star.
A powerful clinical artificial intelligence tool developed by biomedical informatics researchers has demonstrated remarkable accuracy on all three parts of the United States Medical Licensing Exam (Step exams), according to a new article.
An aerodynamic material that mimics shark skin helps planes fly with less drag – and it can be added to existing aircraft like a decal
The exoplanet K2-18b is generating headlines because researchers announced what could be evidence of life on the planet. The JWST detected a pair of atmospheric chemicals that on Earth are produced by living organisms. The astronomers responsible for the results are quick to remind everyone that they have not found life, only chemicals that could indicate the presence of life. The results beg a larger question, though: Can the JWST really ever detect life?
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