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I’ve been reflecting on the disappointing outcomes and the reaction to Sarepta Therapeutics’ recently announced clinical trial results for its Duchenne muscular dystrophy treatments, AMONDYS 45 (casimersen) and VYONDYS 53 (golodirsen). The tension is evident: Families want treatments that benefit patients, while critics note the evidence reveals a different story. Duchenne muscular dystrophy is a relentless disease. When a company suggests it […]

The post Hope, Evidence, and Hard Questions in Duchenne Muscular Dystrophy first appeared on Science-Based Medicine.

Orforglipron, a GLP-1 drug taken as a pill, achieved positive results in people with obesity and type 2 diabetes, although it seems less effective than injectable drugs

The health impacts of men losing their Y chromosome from their cells are increasingly coming to light, with the loss playing a complicated role in the most common form of lung cancer

MIT engineers have created an ultrasonic device that rapidly frees water from materials designed to absorb moisture from the air. Instead of waiting hours for heat to evaporate the trapped water, the system uses high-frequency vibrations to release droplets in just minutes. It can be powered by a small solar cell and programmed to cycle continuously throughout the day. The breakthrough could help communities with limited access to fresh water.

Operating a new device named the Fusion Z-pinch Experiment 3, or FuZE-3, Zap Energy has now achieved plasmas with electron pressures as high as 830 megapascals (MPa), or 1.6 gigapascals (GPa) total, comparable to the pressures found deep below Earth’s crust.

All of the proposals floating around out there for invoking dynamical dark energy are a little on the weak side. In many cases, they raise more questions than answers.

Researchers using the NASA/ESA/CSA James Webb Space Telescope have confirmed an actively growing supermassive black hole within a galaxy just 570 million years after the Big Bang. Part of a class of small, very distant galaxies that have mystified astronomers, CANUCS-LRD-z8.6 represents a vital piece of this puzzle that challenges existing theories about the formation of galaxies and black holes in the early Universe. The discovery connects early black holes with the luminous quasars we observe today.

A newly discovered cluster of objects called the “inner kernel” of the Kuiper belt could teach us about the early history of the solar system – including the movement of Neptune

When engineers struggled to make 3D printer nozzles narrow enough for their needs, they turned to nature and found the proboscis of a female mosquito had exactly the properties they needed

The depths of the Arctic Ocean have warmed more than scientists expected. New research has placed the blame on warmer water from Greenland

Observations of a merging black hole further supports the Area Theorem of black hole thermodynamics, which states that the event horizon of a black hole produced by two merging black holes must have a surface area no less than the areas of the original two.

Body fat, often reviled, is actually a vital organ that contributes to your health and well-being. It is time for us to stop vilifying fat and to start exploring how we can harness its power

Botanist James Wong is constantly asked if he plays music to his army of plants. Time to put this notion to the test...

Brian Eno and Beatie Wolfe's album Liminal is being transmitted into space by Nobel laureate Robert Wilson. They give Chelsea Whyte the lowdown

The books, TV, games and more that New Scientist staff have enjoyed this week

Mary Roach's new book Replaceable You explores what we do when bits of our bodies break down or need switching out. It makes for a brilliant read – just beware the gory details, warns Carissa Wong

In the latest in our imagined history of inventions yet to come, Future Chronicles columnist Rowan Hooper reveals how an ingenious way to avoid being swamped by AI content was invented in the late 2020s

Sport utility vehicles and other larger cars are becoming more and more common, and this is dangerous for our health in many ways. But we have ways to counter "carspreading", says Anthony Laverty

Feedback is delighted to discover that two academics have taken a scholarly interest in dad jokes, but is unsurprised by their key finding: the people who most enjoy dad jokes are dads

Attempts to describe quantum physics are rarely enjoyable, but Paul Davies' zeal in Quantum 2.0 sometimes steers too close to hype, finds Karmela Padavic-Callaghan